Monitoring transgene expression with positron emission tomography: a preclinical evaluation

Anne Rixt Buursma


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For many patients who can not be effectively treated with standard treatments, gene therapy could offer relief. Over the past years, several preclinical studies have shown exciting results. Especially for the treatment of cancer, various gene therapy strategies have been studied and successfully applied in preclinical settings. One of these strategies is suicide gene therapy. In this approach, tumor cells are transfected with a suicide gene, and after transfection, the cells are able to convert a prodrug into its toxic metabolites. Upon treatment with the prodrug, the transfected cells are killed. The suicide gene/prodrug system that has been studied most extensively, is the herpes simplex virus thymidine kinase (HSVtk) gene in combination with ganciclovir (GCV) ... Zie: Summary
Originele taal-2English
KwalificatieDoctor of Philosophy
  • Mulder, Nanno, Supervisor
  • Vaalburg, Willem, Supervisor
  • Hospers, Geke, Co-supervisor
  • de Vries, Erik, Co-supervisor
Datum van toekenning27-mrt-2006
Plaats van publicatie[Groningen]
StatusPublished - 2006

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