Moonlighting proteins: An intriguing mode of multitasking

Daphne Huberts, I.J. van der Klei

OnderzoeksoutputAcademicpeer review

274 Citaten (Scopus)
602 Downloads (Pure)


Proteins are macromolecules, which perform a large variety of functions. Most of them have only a single function, but an increasing number of proteins are being identified as multifunctional. Moonlighting proteins form a special class of multifunctional proteins. They perform multiple autonomous and often unrelated functions without partitioning these functions into different domains of the protein. Striking examples are enzymes, which in addition to their catalytic function are involved in fully unrelated processes such as autophagy, protein transport or DNA maintenance. In this contribution we present an overview of our current knowledge of moonlighting proteins and discuss the significant implications for biomedical and fundamental research. (C) 2010 Elsevier B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)520-525
Aantal pagina's6
TijdschriftBiochimica et Biophysica Acta-Molecular Cell Research
Nummer van het tijdschrift4
StatusPublished - apr-2010

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