@inproceedings{769e424a4af94621983062492b070572,
title = "MR-DTI and PET multimodal imaging of dopamine release within subdivisions of basal ganglia",
abstract = "The basal ganglia is a group of anatomical nuclei, functionally organised into limbic, associative and sensorimotor regions, which plays a central role in dopamine related neurological and psychiatric disorders. In this study, we combine two imaging modalities to enable the measurement of dopamine release in functionally related subdivisions of the basal ganglia. [11C]-(+)-PHNO Positron Emission Tomography (PET) measurements in the living human brain pre- and post-administration of amphetamine allow for the estimation of regional dopamine release. Combined Magnetic Resonance Diffusion Tensor Imaging (MR-DTI) data allows for the definition of functional territories of the basal ganglia from connectivity information. The results suggest that there is a difference in dopamine release among the connectivity derived functional subdivisions. Dopamine release is highest in the limbic area followed by the sensorimotor and then the associative area with this pattern reflected in both striatum and pallidum.",
author = "A. Tziortzi and G. Searle and C. Tsoumpas and C. Long and P. Shotbolt and E. Rabiner and M. Jenkinson and Gunn, {R. N.}",
year = "2011",
doi = "10.1088/1742-6596/317/1/012005",
language = "English",
volume = "317",
series = "Journal of Physics: Conference Series",
publisher = "IoP Publishing",
booktitle = "International Conference on Image Optimisation in Nuclear Medicine (OptiNM)",
edition = "1",
note = "International Conference on Image Optimisation in Nuclear Medicine, OptiNM 2011 ; Conference date: 23-03-2011 Through 26-03-2011",
}