mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

Marti Cadena Sandoval; Alexander Heberle; Ulrike Rehbein; Cecilia Barile; Jose Miguel Ramos Pittol; Kathrin Thedieck

doi:10.3389/fragi.2021.761333

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases

Marti Cadena Sandoval, Alexander Heberle, Ulrike Rehbein, Cecilia Barile, Jose Miguel Ramos Pittol, Kathrin Thedieck^*

^*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review article › peer review

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The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 and integrates growth factor, nutrient and stress signals. Aging is a dynamic process characterized by declining cellular survival, renewal, and fertility. Stressors elicited by aging hallmarks such as mitochondrial malfunction, loss of proteostasis, genomic instability and telomere shortening impinge on mTORC1 thereby contributing to age-related processes. Stress granules (SGs) constitute a cytoplasmic non-membranous compartment formed by RNA-protein aggregates, which control RNA metabolism, signaling, and survival under stress. Increasing evidence reveals complex crosstalk between the mTORC1 network and SGs. In this review, we cover stressors elicited by aging hallmarks that impinge on mTORC1 and SGs. We discuss their interplay, and we highlight possible links in the context of aging and age-related diseases.

Originele taal-2	English
Artikelnummer	761333
Aantal pagina's	13
Tijdschrift	Frontiers in Aging
Volume	2
DOI's	https://doi.org/10.3389/fragi.2021.761333
Status	Published - 13-okt.-2021

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10.3389/fragi.2021.761333Licentie: CC BY

mTORC1 Crosstalk With Stress Granules in Aging and Age-Related DiseasesFinal publisher's version, 1,36 MBLicentie: CC BY

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title = "mTORC1 Crosstalk With Stress Granules in Aging and Age-Related Diseases",

abstract = "The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 and integrates growth factor, nutrient and stress signals. Aging is a dynamic process characterized by declining cellular survival, renewal, and fertility. Stressors elicited by aging hallmarks such as mitochondrial malfunction, loss of proteostasis, genomic instability and telomere shortening impinge on mTORC1 thereby contributing to age-related processes. Stress granules (SGs) constitute a cytoplasmic non-membranous compartment formed by RNA-protein aggregates, which control RNA metabolism, signaling, and survival under stress. Increasing evidence reveals complex crosstalk between the mTORC1 network and SGs. In this review, we cover stressors elicited by aging hallmarks that impinge on mTORC1 and SGs. We discuss their interplay, and we highlight possible links in the context of aging and age-related diseases.",

author = "{Cadena Sandoval}, Marti and Alexander Heberle and Ulrike Rehbein and Cecilia Barile and {Ramos Pittol}, {Jose Miguel} and Kathrin Thedieck",

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doi = "10.3389/fragi.2021.761333",

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AU - Cadena Sandoval, Marti

AU - Heberle, Alexander

AU - Rehbein, Ulrike

AU - Barile, Cecilia

AU - Ramos Pittol, Jose Miguel

AU - Thedieck, Kathrin

PY - 2021/10/13

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N2 - The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 and integrates growth factor, nutrient and stress signals. Aging is a dynamic process characterized by declining cellular survival, renewal, and fertility. Stressors elicited by aging hallmarks such as mitochondrial malfunction, loss of proteostasis, genomic instability and telomere shortening impinge on mTORC1 thereby contributing to age-related processes. Stress granules (SGs) constitute a cytoplasmic non-membranous compartment formed by RNA-protein aggregates, which control RNA metabolism, signaling, and survival under stress. Increasing evidence reveals complex crosstalk between the mTORC1 network and SGs. In this review, we cover stressors elicited by aging hallmarks that impinge on mTORC1 and SGs. We discuss their interplay, and we highlight possible links in the context of aging and age-related diseases.

AB - The mechanistic target of rapamycin complex 1 (mTORC1) kinase is a master regulator of metabolism and aging. A complex signaling network converges on mTORC1 and integrates growth factor, nutrient and stress signals. Aging is a dynamic process characterized by declining cellular survival, renewal, and fertility. Stressors elicited by aging hallmarks such as mitochondrial malfunction, loss of proteostasis, genomic instability and telomere shortening impinge on mTORC1 thereby contributing to age-related processes. Stress granules (SGs) constitute a cytoplasmic non-membranous compartment formed by RNA-protein aggregates, which control RNA metabolism, signaling, and survival under stress. Increasing evidence reveals complex crosstalk between the mTORC1 network and SGs. In this review, we cover stressors elicited by aging hallmarks that impinge on mTORC1 and SGs. We discuss their interplay, and we highlight possible links in the context of aging and age-related diseases.

U2 - 10.3389/fragi.2021.761333

DO - 10.3389/fragi.2021.761333

M3 - Review article

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JO - Frontiers in Aging

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