Multi-ancestry genome-wide association study of 21,000 cases and 95,000 controls identifies new risk loci for atopic dermatitis

Lavinia Paternoster*, Marie Standl, Johannes Waage, Hansjoerg Baurecht, Melanie Hotze, David P. Strachan, John A. Curtin, Klaus Bonnelykke, Chao Tian, Atsushi Takahashi, Jorge Esparza-Gordillo, Alexessander Couto Alves, Jacob P. Thyssen, Herman T. den Dekker, Manuel A. Ferreira, Elisabeth Altmaier, Patrick M. A. Sleiman, Feng Li Xiao, Juan R. Gonzalez, Ingo MarenholzBirgit Kalb, Maria Pino-Yanes, Chengjian Xu, Lisbeth Carstensen, Maria M. Groen-Blokhuis, Cristina Venturini, Craig E. Pennell, Sheila J. Barton, Albert M. Levin, Ivan Curjuric, Mariona Bustamante, Eskil Kreiner-Moller, Gabrielle A. Lockett, Jonas Bacelis, Supinda Bunyavanich, Rachel A. Myers, Anja Matanovic, Ashish Kumar, Joyce Y. Tung, Tomomitsu Hirota, Michiaki Kubo, Wendy L. McArdle, A. John Henderson, John P. Kemp, Jie Zheng, George Davey Smith, Franz Rueschendorf, Dirkje S. Postma, Scott T. Weiss, Gerard H. Koppelman, AAGC, EAGLE Consortium

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

284 Citaten (Scopus)

Samenvatting

Genetic association studies have identified 21 loci associated with atopic dermatitis risk predominantly in populations of European ancestry. To identify further susceptibility loci for this common, complex skin disease, we performed a meta-analysis of >15 million genetic variants in 21,399 cases and 95,464 controls from populations of European, African, Japanese and Latino ancestry, followed by replication in 32,059 cases and 228,628 controls from 18 studies. We identified ten new risk loci, bringing the total number of known atopic dermatitis risk loci to 31 (with new secondary signals at four of these loci). Notably, the new loci include candidate genes with roles in the regulation of innate host defenses and T cell function, underscoring the important contribution of (auto) immune mechanisms to atopic dermatitis pathogenesis.

Originele taal-2English
Pagina's (van-tot)1449-1458
Aantal pagina's10
TijdschriftNature Genetics
Volume47
Nummer van het tijdschrift12
DOI's
StatusPublished - dec-2015

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