@article{2dc52ee33eea45279026c0cd1362669a,
title = "Multi-ancestry genome-wide gene-smoking interaction study of 387,272 individuals identifies new loci associated with serum lipids",
abstract = "The concentrations of high- and low-density-lipoprotein cholesterol and triglycerides are influenced by smoking, but it is unknown whether genetic associations with lipids may be modified by smoking. We conducted a multi-ancestry genome-wide gene-smoking interaction study in 133,805 individuals with follow-up in an additional 253,467 individuals. Combined meta-analyses identified 13 new loci associated with lipids, some of which were detected only because association differed by smoking status. Additionally, we demonstrate the importance of including diverse populations, particularly in studies of interactions with lifestyle factors, where genomic and lifestyle differences by ancestry may contribute to novel findings.",
keywords = "ENVIRONMENT INTERACTION, GENOTYPE IMPUTATION, NICOTINE METABOLISM, RISK LOCI, METAANALYSIS, ARCHITECTURE, CHOLESTEROL, CIGARETTES, VARIANTS, SUSCEPTIBILITY",
author = "{COGENT-Kidney Consortium} and {EPIC-InterAct Consortium} and {Understanding Soc Sci Grp} and {Lifelines Cohort} and Bentley, {Amy R.} and Sung, {Yun J.} and Brown, {Michael R.} and Winkler, {Thomas W.} and Kraja, {Aldi T.} and Ioanna Ntalla and Karen Schwander and Daniel Chasman and Elise Lim and Xuan Deng and Xiuqing Guo and Jingmin Liu and Yingchang Lu and Ching-Yu Cheng and Xueling Sim and Dina Vojinovic and Huffman, {Jennifer E.} and Musani, {Solomon K.} and Changwei Li and Feitosa, {Mary F.} and Richard, {Melissa A.} and Raymond Noordam and Jenna Baker and Guanjie Chen and Hugues Aschard and Bartz, {Traci M.} and Jingzhong Ding and Rajkumar Dorajoo and Manning, {Alisa K.} and Tuomo Rankinen and Albert Smith and Tajuddin, {Salman M.} and Wei Zhao and Mariaelisa Graff and Maris Alver and Mathilde Boissel and Yanick Hagemeijer and Nolte, {Ilja M.} and Bram Prins and Said, {M. Abdullah} and {van der Most}, {Peter J.} and Zhao, {Jing Hua} and Marzyeh Amini and {de Vries}, {Paul S.} and Eppinga, {Ruben N.} and Harold Snieder and Oldehinkel, {Albertine J.} and Penninx, {Brenda W. J. H.} and {van der Harst}, Pim and Wang, {Ya Xing}",
year = "2019",
month = apr,
doi = "10.1038/s41588-019-0378-y",
language = "English",
volume = "51",
pages = "636--+",
journal = "Nature Genetics",
issn = "1061-4036",
publisher = "Nature Publishing Group",
number = "4",
}