Multi-domain cognitive impairments at school age in very preterm-born children compared to term-born peers

Elise Roze*, Sijmen A. Reijneveld, Roy E. Stewart, Arend F. Bos

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ArticleAcademicpeer review

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Background Preterm infants are at risk for functional impairments in motor, cognitive, and behavioral development that may persist into childhood. The aim of this study was to determine the co-occurrence of cognitive impairments in multiple cognitive domains at school age in very preterm born children compared to term-born children. Methods Comparative study including 60 very preterm-born children (gestational age = 2), versus 3% of the controls (odds ratio, OR 4.65, 95%-confidence interval, CI 1.33-16.35). For multiple suspect-abnormal cognitive outcomes, rates were 55% versus 25% (OR 3.02, 95%-CI 1.49-6.12). We found no pattern of co-occurrence of cognitive impairments among preterm children that deviated from term-born controls. However, low performance IQ was more frequently accompanied by additional cognitive impairments in preterms than in controls (OR 5.43, 95%-CI 1.75-16.81). Conclusions A majority of preterm children showed co-occurrence of impairments in multiple cognitive domains, but with no specific pattern of impairments. The occurrence of multi-domain cognitive impairments is higher in preterms but this seems to reflect a general increase, not one with a pattern specific for preterm-born children.

Originele taal-2English
Aantal pagina's9
TijdschriftBMC Pediatrics
Nummer van het tijdschrift1
StatusE-pub ahead of print - 13-apr-2021

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