Multi-modal analysis of tumor-derived extracellular vesicles immunocaptured from plasma

Pepijn Beekman*, Agustin Enciso-Martinez, Melissa Piontek, Leon Terstappen, Wouter Roos, Cees Otto, Séverine Le Gac

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

Samenvatting

Extracellular vesicles have emerged in recent years as highly promising for understanding cell communication, drug delivery, and medical applications. Specifically, tumor-derived extracellular vesicles (tdEVs) have demonstrated excellent prognostic value in cancer diagnostics compared to imaging approaches. Despite the growing body of expertise regarding EVs, great challenges remain, notably in their handling and characterization. In complex media, other particles with similar characteristics may occlude measurements. Here, a platform is presented for the immunocapturing of tdEVs for identifying their origin followed by further multi-modal analysis by Raman spectroscopy, confocal microscopy and atomic force microscopy (AFM).

Originele taal-2English
TitelMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences
UitgeverijChemical and Biological Microsystems Society
Pagina's404-405
Aantal pagina's2
ISBN van elektronische versie9781733419017
StatusPublished - 2020
Evenement24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020 - Virtual, Online
Duur: 4-okt.-20209-okt.-2020

Publicatie series

NaamMicroTAS 2020 - 24th International Conference on Miniaturized Systems for Chemistry and Life Sciences

Conference

Conference24th International Conference on Miniaturized Systems for Chemistry and Life Sciences, MicroTAS 2020
StadVirtual, Online
Periode04/10/202009/10/2020

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