Multi-omics approaches to understand respiratory disease


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    The main scope of this thesis is to improve our understanding of the biological mechanisms of allergic disease, in particular asthma and rhinitis, by applying multi-omics approaches. We collected multi-omics data from the genome, epigenome, bulk and single-cell transcriptome, and the exposome. By applying association and machine learning approaches, we investigated epigenetic mechanisms of the development of allergic disease, revealed cell-type specific molecular regulation of asthma risk variants, identified biomarkers of allergy, and provided a prediction tool for allergic disease.
    Originele taal-2English
    KwalificatieDoctor of Philosophy
    Toekennende instantie
    • Rijksuniversiteit Groningen
    • Koppelman, Gerard, Supervisor
    • Xu, Chengjian, Co-supervisor
    Datum van toekenning15-sep-2021
    Plaats van publicatie[Groningen]
    StatusPublished - 2021

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