Multicomponent diversity and enzymatic enantioselectivity as a route towards both enantiomers of alpha-amino acids: A model study

Wiktor Szymanski, Ryszard Ostaszewski*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

33 Citaten (Scopus)

Samenvatting

A model study on a new, enantioconvergent method for the synthesis of chiral, nonracemic alpha-amino acids is presented. alpha-Acetoxyamides obtained in a Passerini multicomponent reaction are selectively hydrolyzed by Wheat Germ lipase. Studies on conversion of the thus obtained, enantiomerically enriched alpha-hydroxyamides into alpha-aminoamides are presented. Products of these reactions are then hydrolyzed to give alpha-amino acids. (c) 2006 Elsevier Ltd. All rights reserved.

Originele taal-2English
Pagina's (van-tot)2667-2671
Aantal pagina's5
TijdschriftTetrahedron-Asymmetry
Volume17
Nummer van het tijdschrift18
DOI's
StatusPublished - 16-okt-2006
Extern gepubliceerdJa

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