Multicomponent Reaction Based Synthesis of 1-Tetrazolylimidazo[1,5- a]pyridines

Santosh Kurhade, Elmar Diekstra, Fandi Sutanto, Katarzyna Kurpiewska, Justyna Kalinowska-Tłuścik, Alexander Dömling

OnderzoeksoutputAcademicpeer review

24 Citaten (Scopus)
286 Downloads (Pure)

Samenvatting

A series of unprecedented tetrazole-linked imidazo[1,5- a]pyridines are synthesized from simple and readily available building blocks. The reaction sequence involves an azido-Ugi-deprotection reaction followed by an acetic anhydride-mediated N-acylation-cyclization process to afford the target heterocycle. Furthermore, the scope of the methodology was extended to diverse R3-substitutions by employing commercial anhydrides, acid chlorides, and acids as an acyl component. The scope for the postmodification reactions are explored and the usefulness of the synthesis is exemplified by an improved three-step synthesis of a guanylate cyclase stimulator.
Originele taal-2English
Pagina's (van-tot)3871-3874
Aantal pagina's4
TijdschriftOrganic letters
Volume20
Nummer van het tijdschrift13
DOI's
StatusPublished - 6-jul.-2018

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