Multifunctional Biomimetic Nanovaccines Based on Photothermal and Weak-immunostimulatory Nanoparticulate Cores for the Immunotherapy of Solid Tumors

Jiachen Li, Di Huang, Ruoyu Cheng, Patrícia Figueiredo, Flavia Fontana, Alexandra Correia, Shiqi Wang, Zehua Liu, Marianna Kemell, Giulia Torrieri, Ermei M. Mäkilä, Jarno J. Salonen, Jouni Hirvonen, Yan Gao, Jialiang Li, Zhenyang Luo*, Hélder A. Santos*, Bing Xia*

*Corresponding author voor dit werk

    OnderzoeksoutputAcademicpeer review

    45 Citaten (Scopus)
    185 Downloads (Pure)

    Samenvatting

    Here, an alternative strategy of choosing photothermal and weak-immunostimulatory porous silicon@Au nanocomposites as particulate cores to prepare a biomimetic nanovaccine, is reported to improve its biosafety and immunotherapeutic efficacy for solid tumors. A quantitative analysis method is used to calculate the loading amount of cancer cell membranes onto porous silicon@Au nanocomposites. Assisted with foreign body responses, these exogenous nanoparticulate cores with weak immunostimulatory effect can still efficiently deliver cancer cell membranes into dendritic cells to activate them and the downstream antitumor immunity, resulting in no occurrence of solid tumors and the survival of all immunized mice during 55-day observation. In addition, this nanovaccine as a photothermal therapeutic agent synergized with additional immunotherapies can significantly inhibit the growth and metastasis of established solid tumors, via the initiation of the antitumor immune responses in the body and the reversion of their immunosuppressive microenvironments. Considering the versatile surface engineering of porous silicon nanoparticles, this strategy developed here is beneficial to construct multifunctional nanovaccines with better biosafety and more diagnosis or therapeutic modalities against the occurrence, recurrence or metastasis of solid tumors in future clinical practice.
    Originele taal-2English
    Artikelnummer2108012
    Aantal pagina's12
    TijdschriftAdvanced materials
    Volume34
    Nummer van het tijdschrift9
    Vroegere onlinedatum7-dec.-2021
    DOI's
    StatusPublished - 3-mrt.-2022

    Vingerafdruk

    Duik in de onderzoeksthema's van 'Multifunctional Biomimetic Nanovaccines Based on Photothermal and Weak-immunostimulatory Nanoparticulate Cores for the Immunotherapy of Solid Tumors'. Samen vormen ze een unieke vingerafdruk.

    Citeer dit