The fracture strength of metal foams depends sensitively on the properties of the constituent material as well as the cellular architecture. A change in microscopic properties carries over to the macroscopic scale through an alteration of the mesoscopic damage and fracture mechanisms. In this paper we study these dependencies using a modelling framework that takes all these ingredients into account. We have developed a micromechanical model based on a discrete Voronoi representation of cellular metals that incorporates power-law strain hardening and damage development of the cell wall material. The influence of the relative density and material strain hardening on the cell wall damage behavior and overall fracture response is analyzed in detail. The effect of the cellular architecture is studied by varying the cell shape anisotropy and structural randomness. We also simulate the effect of post-processing heat treatments on the solid material plastic and fracture properties and how this affects the overall fracture profile and damage development. Finally, all material and architectural effects are summarized in a strength versus ductility graph, identifying trends for improved design of metallic foams. (C) 2011 Elsevier Ltd. All rights reserved.