Samenvatting
The coupling of organolithium reagents, including strongly hindered examples, at cryogenic temperatures (as low as -78 degrees C) has been achieved with high-reactivity Pd-NHC catalysts. A temperature-dependent chemoselectivity trigger has been developed for the selective coupling of aryl bromides in the presence of chlorides. Building on this, a one-pot, sequential coupling strategy is presented for the rapid construction of advanced building blocks. Importantly, one-shot addition of alkyllithium compounds to Pd cross-coupling reactions has been achieved, eliminating the need for slow addition by syringe pump.
Originele taal-2 | English |
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Pagina's (van-tot) | 9180-9184 |
Aantal pagina's | 5 |
Tijdschrift | Chemistry |
Volume | 25 |
Nummer van het tijdschrift | 39 |
DOI's | |
Status | Published - 11-jul.-2019 |