Myeloid derived suppressor cells-An overview of combat strategies to increase immunotherapy efficacy

Oana Draghiciu, Joyce Lubbers, Hans W. Nijman, Toos Daemen*

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: Review articleAcademicpeer review

155 Citaten (Scopus)

Samenvatting

Myeloid-derived suppressor cells (MDSCs) contribute to tumor-mediated immune escape and negatively correlate with overall survival of cancer patients. Nowadays, a variety of methods to target MDSCs are being investigated. Based on the intervention stage of MDSCs, namely development, expansion and activation, function and turnover, these methods can be divided into: (I) prevention or differentiation to mature cells, (II) blockade of MDSC expansion and activation, (III) inhibition of MDSC suppressive activity or (IV) depletion of intratumoral MDSCs. This review describes effective mono-or multimodal-therapies that target MDSCs for the benefit of cancer treatment.

Originele taal-2English
Artikelnummere954829
Aantal pagina's10
TijdschriftOncoImmunology
Volume4
Nummer van het tijdschrift1
DOI's
StatusPublished - 2015

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