Natural and bioinspired excipients for dry powder inhalation formulations

Daan Zillen, Max Beugeling, Wouter L.J. Hinrichs*, Henderik W. Frijlink, Floris Grasmeijer

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)
113 Downloads (Pure)

Samenvatting

Pulmonary drug delivery can have several advantages over other administration routes, in particular when using dry powder formulations. Such dry powder inhalation formulations generally include natural and bio-inspired excipients, which, among other purposes, are used to improve dosing reproducibility and aerosolization performance. Amino acids can enhance powder dispersibility and provide protection against moisture uptake. Sugars are used as drug-carrying diluents, stabilizers for biopharmaceuticals, and surface enrichers. Lipids and lipid-like excipients can reduce interparticle adhesive forces and are also used as constituents of liposomal drug delivery systems. Finally, biodegradable polymers are used to facilitate sustained release and targeted drug delivery. Despite their promise, pulmonary toxicity of many of the discussed excipients remains largely unknown and requires attention in future research.

Originele taal-2English
Artikelnummer101497
Aantal pagina's17
TijdschriftCurrent Opinion in Colloid and Interface Science
Volume56
Vroegere onlinedatum12-aug-2021
DOI's
StatusPublished - dec-2021

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