NEAT1 and CHROMR lncRNAs: a promising diagnostic tool for diffuse large B-cell lymphoma especially in elderly patients

Ali Rajabi, Ali Saber, Joost Kluiver, Anke van den Berg, Mohammad Ali Hosseinpourfeizi, Reza Safaralizadeh*

*Corresponding author voor dit werk

OnderzoeksoutputAcademicpeer review

Samenvatting

Background: Long non-coding (lnc) RNAs have crucial regulatory roles in molecular pathways, and their dysregulation is associated with the pathogenesis of malignancies such as Diffuse large B-cell lymphoma (DLBCL). Therefore, we aimed to study the NEAT1 and CHROMR expression in DLBCL and explore their association with clinicopathological characteristics.

Methods & materials: DLBCL and non-tumor lymph node specimens were obtained to assess the expression levels.

Results: NEAT1 and CHROMR expressions were significantly increased in DLBCL, and were linked with the age of DLBCL patients (aged >60). NEAT1 and CHROMR overexpression may serve as moderate-to-good diagnostic biomarkers, with NEAT1 and CHROMR exhibiting area under the curve values of 0.781 and 0.831, respectively.

Originele taal-2English
Pagina's (van-tot)685-693
Aantal pagina's9
TijdschriftBiomarkers in medicine
Volume18
Nummer van het tijdschrift15-16
DOI's
StatusPublished - 17-aug.-2024

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