Neurobiology and neuroimmunology of Tourette's syndrome: an update

PJ Hoekstra*, GM Anderson, PC Limburg, J Korf, CGM Kallenberg, RB Minderaa

*Corresponding author voor dit werk

Onderzoeksoutputpeer review

72 Citaten (Scopus)

Samenvatting

Tourette's syndrome is a childhood-onset neuropsychiatric disorder characterized by the presence of both multiple motor and vocal tics. While the pathogenesis at a molecular and cellular level remains unknown, structural and functional neuroimaging studies point to the involvement of the basal ganglia and related cortico-striato-thalamo-cortical circuits as the neuroanatomical site for Tourette's syndrome. Moreover, Tourette's syndrome has a strong genetic component, and considerable progress has been made in understanding the mode of transmission and in identifying potential genomic loci. Summaries of recent findings in these areas will be reviewed, followed by a critical overview of findings both supporting and challenging the proposed autoimmune hypothesis of Tourette's syndrome. We conclude that Tourette's syndrome is a heterogeneous disorder, and that immune factors may indeed be involved in some patients.

Originele taal-2English
Pagina's (van-tot)886-898
Aantal pagina's13
TijdschriftCellular and molecular life sciences
Volume61
Nummer van het tijdschrift7-8
DOI's
StatusPublished - apr.-2004

Vingerafdruk

Duik in de onderzoeksthema's van 'Neurobiology and neuroimmunology of Tourette's syndrome: an update'. Samen vormen ze een unieke vingerafdruk.

Citeer dit