Neuroendocrinology of insulin resistance: metabolic and endocrine aspects of adiposity

G van Dijk*, K de Vries, L Benthem, C Nyakas, B Buwalda, AJW Scheurink

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

22 Citaten (Scopus)
331 Downloads (Pure)


Abdominal obesity is a major risk factor to attract the insulin resistance syndrome. It is proposed that abdominal obesity exposes the liver to elevated levels of free fatty acids, which activate a neuroendocrine reflex, leading to increased circulating levels of glucocorticoids. Besides directly attenuating peripheral insulin signaling, glucocorticoids oppose the activity of central nervous regulatory systems that stimulate insulin action. Among the factors that promote insulin action is leptin. Leptin regulates peripheral fuel partitioning and insulin action mainly through hypothalamic neuronal networks, which in turn, regulate endocrine activity of adipose tissue in a way comparable to thiazolidinediones. These are a class of insulin-sensitizing drugs, which exert their antidiabetic effects through the gamma isoform of peroxisome proliferator-activated receptor (PPAR-gamma). Since glucocorticoids oppose leptin action at several levels of control (including the central nervous system, CNS), it is argued that subjects easily develop obesity and associated metabolic disorders. (C) 2003 Elsevier B.V. All rights reserved.

Originele taal-2English
Pagina's (van-tot)31-42
Aantal pagina's12
TijdschriftEuropean Journal of Pharmacology
Nummer van het tijdschrift1-3
StatusPublished - 7-nov-2003
Evenement3rd EJP Spring Meeting on Drug Targets for Psychiatric Disorders - , Netherlands
Duur: 13-jun-200316-jun-2003

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