Never tear us a-PARP: Dealing with DNA lesions during mitosis

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Samenvatting

Tumors defective in homologous recombination (HR) are highly sensitive to poly ADP-ribose polymerase (PARP) inhibition, however the cell biological mechanisms underlying this synthetic lethality remain elusive. We recently identified that PARP inhibitor-induced DNA lesions persist until mitosis, subsequently causing mitotic chromatin bridges, multinucleation and apoptosis. Here, we discuss the implications of these findings.

Originele taal-2English
Artikelnummere1382670
Aantal pagina's4
TijdschriftMolecular & Cellular Oncology
Volume5
Nummer van het tijdschrift1
DOI's
StatusPublished - 2018

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