New insights and perspectives on the genetics of obsessive-compulsive disorder

Gwyneth Zai*, Csaba Barta, Danielle Cath, Valsamma Eapen, Daniel Geller, Edna Grunblatt

*Bijbehorende auteur voor dit werk

    Onderzoeksoutputpeer review

    15 Citaten (Scopus)
    96 Downloads (Pure)

    Samenvatting

    Psychiatric genetic research has exploded in search of polygenic risk factors over the past decade, but because of the complexity and heterogeneity of mental illnesses, using the current understanding of the genome has not reached the conclusion of finding a cause for psychiatric disorders. Obsessive-compulsive disorder is a relatively common and often debilitating neuropsychiatric disorder that has not been the primary focus in psychiatric research. Clinicians and researchers who have dedicated to investigate the genetics of obsessive-compulsive disorder have detected a strong genetic involvement. This review will provide an update and a new perspective on the current understanding of the genetics of obsessive-compulsive disorder, which includes epidemiological data, family and twins studies, candidate gene studies, genome-wide association studies, copy-number variants, imaging genetics, epigenetics, and gene-environment interaction. Copyright (C) 2019 Wolters Kluwer Health, Inc. All rights reserved.

    Originele taal-2English
    Pagina's (van-tot)142-151
    Aantal pagina's10
    TijdschriftPSYCHIATRIC GENETICS
    Volume29
    Nummer van het tijdschrift5
    DOI's
    StatusPublished - okt.-2019

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