New vessel formation and aberrant VEGF/VEGFR signaling in acute leukemia: Does it matter?

ESJM De Bont*, VME Neefjes, S Rosati, E Vellenga, WA Kamps

*Corresponding author voor dit werk

Onderzoeksoutputpeer review

11 Citaten (Scopus)

Samenvatting

Although many patients with acute leukemia achieve a hematological complete remission with aggressive intensive therapy protocols, a large proportion shows reoccurrence of disease. Novel strategies are warranted. In acute leukemia new vessel formation is observed. New vessel formation is the result of angiogenesis and vasculogenesis. The degree of neovascularization in the bone marrow is correlated with vascular endothelial growth factor (VEGF) expression in the leukemic cells. The present review discusses the impact of new vessel formation related to acute leukemia, the relation with various angiogenic factors and will focus on VEGF/VEGF receptor signaling.

Originele taal-2English
Pagina's (van-tot)1901-1909
Aantal pagina's9
TijdschriftLeukemia and Lymphoma
Volume43
Nummer van het tijdschrift10
DOI's
StatusPublished - okt.-2002

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