TY - JOUR
T1 - No Obvious Role for Suspicious Oral Pathogens in Arthritis Development
AU - Rahajoe, Poerwati S
AU - de Smit, Menke J
AU - Raveling-Eelsing, Elisabeth
AU - du Teil Espina, Marines
AU - Stobernack, Tim
AU - Lisotto, Paola
AU - Harmsen, Hermie J M
AU - van Dijl, Jan Maarten
AU - Kertia, Nyoman
AU - Vissink, Arjan
AU - Westra, Johanna
PY - 2021/9/10
Y1 - 2021/9/10
N2 - A particular role for Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) has been suggested in periodontitis and rheumatoid arthritis (RA), as these bacteria could initiate the formation of rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPA). We assessed whether serum antibodies against Pg and Aa in RA patients and non-RA controls reflect the subgingival presence of Pg and Aa, and evaluated the relationship of these antibodies to the severity of periodontal inflammation and RA-specific serum autoantibodies. In 70 Indonesian RA patients and 70 non-RA controls, the subgingival presence of Pg and Aa was assessed by bacterial 16S rRNA gene sequencing, and serum IgG levels specific for Pg and Aa were determined. In parallel, serum levels of ACPA (ACPA:IgG,IgA) and RF (RF:IgM,IgA) were measured. The extent of periodontal inflammation was assessed by the periodontal inflamed surface area. In both RA patients and the controls, the presence of subgingival Pg and Aa was comparable, anti-Pg and anti-Aa antibody levels were associated with the subgingival presence of Pg and Aa, and anti-Pg did not correlate with ACPA or RF levels. The subgingival Pg and Aa were not related to RA. No noteworthy correlation was detected between the antibodies against Pg and Aa, and RA-specific autoantibodies.
AB - A particular role for Porphyromonas gingivalis (Pg) and Aggregatibacter actinomycetemcomitans (Aa) has been suggested in periodontitis and rheumatoid arthritis (RA), as these bacteria could initiate the formation of rheumatoid factor (RF) and anticitrullinated protein autoantibodies (ACPA). We assessed whether serum antibodies against Pg and Aa in RA patients and non-RA controls reflect the subgingival presence of Pg and Aa, and evaluated the relationship of these antibodies to the severity of periodontal inflammation and RA-specific serum autoantibodies. In 70 Indonesian RA patients and 70 non-RA controls, the subgingival presence of Pg and Aa was assessed by bacterial 16S rRNA gene sequencing, and serum IgG levels specific for Pg and Aa were determined. In parallel, serum levels of ACPA (ACPA:IgG,IgA) and RF (RF:IgM,IgA) were measured. The extent of periodontal inflammation was assessed by the periodontal inflamed surface area. In both RA patients and the controls, the presence of subgingival Pg and Aa was comparable, anti-Pg and anti-Aa antibody levels were associated with the subgingival presence of Pg and Aa, and anti-Pg did not correlate with ACPA or RF levels. The subgingival Pg and Aa were not related to RA. No noteworthy correlation was detected between the antibodies against Pg and Aa, and RA-specific autoantibodies.
KW - rheumatoid arthritis
KW - periodontitis
KW - Aggregatibacter actinomycetemcomitans
KW - Porphyromonas gingivalis
KW - rheumatoid factor
KW - anticitrullinated protein antibodies
KW - risk factors
KW - INFLAMED SURFACE-AREA
KW - PORPHYROMONAS-GINGIVALIS
KW - PERIODONTITIS
KW - ENVIRONMENT
KW - MICROBIOTA
KW - GENE
U2 - 10.3390/ijerph18189560
DO - 10.3390/ijerph18189560
M3 - Article
C2 - 34574484
VL - 18
JO - International Journal of Environmental Research and Public Health
JF - International Journal of Environmental Research and Public Health
SN - 1661-7827
IS - 18
M1 - 9560
ER -