Nocturnal non-invasive ventilation in addition to rehabilitation in hypercapnic patients with COPD

M.L. Duiverman, J.B. Wempe, G. Bladder, D.F. Jansen, H.A.M. Kerstjens, J.G. Zijlstra, P.J. Wijkstra

OnderzoeksoutputAcademicpeer review

112 Citaten (Scopus)
11 Downloads (Pure)

Samenvatting

Background: Long-term non-invasive positive pressure ventilation (NIPPV) might improve the outcomes of pulmonary rehabilitation in patients with chronic obstructive pulmonary disease (COPD) with chronic respiratory failure. A study was undertaken to investigate whether nocturnal NIPPV in addition to pulmonary rehabilitation improves health-related quality of life, functional status and gas exchange compared with pulmonary rehabilitation alone in patients with COPD with chronic hypercapnic respiratory failure.

Methods: 72 patients with COPD were randomly assigned to nocturnal NIPPV in addition to rehabilitation (n = 37) or rehabilitation alone (n = 35). Outcome measures were assessed before and after the 3-month intervention period.

Results: The Chronic Respiratory Questionnaire total score improved 15.1 points with NIPPV + rehabilitation compared with 8.7 points with rehabilitation alone. The difference of 7.5 points was not significant (p = 0.08). However, compared with rehabilitation alone, the difference in the fatigue domain was greater with NIPPV + rehabilitation (mean difference 3.3 points, p

Conclusion: Non-invasive ventilation augments the benefits of pulmonary rehabilitation in patients with COPD with chronic hypercapnic respiratory failure as it improves several measures of health-related quality of life, functional status and gas exchange.

Originele taal-2English
Pagina's (van-tot)1052-1057
Aantal pagina's6
TijdschriftThorax
Volume63
Nummer van het tijdschrift12
DOI's
StatusPublished - dec-2008

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