Non-coding RNA in Endothelial-to-Mesenchymal Transition

Melanie S Hulshoff, Gonzalo Del Monte-Nieto, Jason Kovacic, Guido Krenning

OnderzoeksoutputAcademicpeer review

28 Citaten (Scopus)
4 Downloads (Pure)

Samenvatting

Endothelial-to-mesenchymal transition (EndMT) is the process wherein endothelial cells lose their typical endothelial cell markers and functions and adopt a mesenchymal-like phenotype. EndMT is required for development of the cardiac valves, the pulmonary and dorsal aorta and arterial maturation, but activation of the EndMT program during adulthood is believed to contribute to several pathologies including organ fibrosis, cardiovascular disease and cancer. Non-coding RNAs, including microRNAs, long non-coding RNAs and circular RNAs, modulate EndMT during development and disease. Here, we review the mechanisms by which non-coding RNAs facilitate or inhibit EndMT during development and disease and provide a perspective on the therapeutic application of non-coding RNAs to treat fibroproliferative cardiovascular disease.

Originele taal-2English
Pagina's (van-tot)1716-1731
Aantal pagina's16
TijdschriftCardiovascular Research
Volume115
Nummer van het tijdschrift12
DOI's
StatusPublished - 1-okt-2019

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