Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours

Pepijn J P van der Aa; Max J H Witjes; Bert van der Vegt; Ed Schuuring; Koos Boeve; Grigory Sidorenkov; Geertruida H de Bock; Sebastiaan A H J de Visscher

doi:10.1111/odi.15235

Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours

Pepijn J P van der Aa, Max J H Witjes, Bert van der Vegt, Ed Schuuring, Koos Boeve, Grigory Sidorenkov, Geertruida H de Bock, Sebastiaan A H J de Visscher^*

^*Corresponding author voor dit werk

Onderzoeksoutput › Academic › peer review

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OBJECTIVES: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).

MATERIALS AND METHODS: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).

RESULTS: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).

CONCLUSION: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.

Originele taal-2	English
Aantal pagina's	10
Tijdschrift	Oral diseases
DOI's	https://doi.org/10.1111/odi.15235
Status	E-pub ahead of print - 30-dec.-2024

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@article{8645cfa5d1d1435bac2bfa1cc936e248,

title = "Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours",

abstract = "OBJECTIVES: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).MATERIALS AND METHODS: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).RESULTS: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).CONCLUSION: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.",

author = "{van der Aa}, {Pepijn J P} and Witjes, {Max J H} and {van der Vegt}, Bert and Ed Schuuring and Koos Boeve and Grigory Sidorenkov and {de Bock}, {Geertruida H} and {de Visscher}, {Sebastiaan A H J}",

note = "{\textcopyright} 2024 The Author(s). Oral Diseases published by John Wiley & Sons Ltd.",

year = "2024",

month = dec,

day = "30",

doi = "10.1111/odi.15235",

language = "English",

journal = "Oral diseases",

issn = "1354-523X",

publisher = "Wiley",

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TY - JOUR

T1 - Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours

AU - van der Aa, Pepijn J P

AU - Witjes, Max J H

AU - van der Vegt, Bert

AU - Schuuring, Ed

AU - Boeve, Koos

AU - Sidorenkov, Grigory

AU - de Bock, Geertruida H

AU - de Visscher, Sebastiaan A H J

PY - 2024/12/30

Y1 - 2024/12/30

N2 - OBJECTIVES: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).MATERIALS AND METHODS: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).RESULTS: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).CONCLUSION: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.

AB - OBJECTIVES: This study aimed to explore differences in demographics, tumour characteristics and outcomes in oral squamous cell carcinoma (OSCC) patients with a history of non-smoking, non-drinking (NSND) versus smoking and/or drinking (SD).MATERIALS AND METHODS: Newly diagnosed OSCC patients undergoing curative surgical treatment were prospectively included in OncoLifeS, a data biobank. Cox regression analysis was performed yielding hazard ratios (HRs) and 95% confidence intervals (95%CIs).RESULTS: 185 patients were included, and 32.4% of patients were NSND; this group represented an older (69 vs. 64.4 years, p < 0.01) and more female-dominated (66.7% vs. 44.5%, p = 0.02) population. NSND patients had more tongue tumours (68.3% vs. 46.4%, p < 0.01) and few floor-of-mouth tumours (1.7% vs. 20.0%, p < 0.01). Locoregional recurrence, overall survival and disease-specific survival risk were similar between the NSND and SD patients. NSND patients had a higher second primary tumour risk compared to SD patients in the multivariable analysis (adjusted HR 3.92, 1.23-12.48, p = 0.02).CONCLUSION: NSND patients with OSCC have a distinct clinicopathological profile compared to SD patients, with a higher risk of second primary tumours after treatment. These differences in risk profiles should be considered in future OSCC management strategies.

U2 - 10.1111/odi.15235

DO - 10.1111/odi.15235

M3 - Article

C2 - 39737774

SN - 1354-523X

JO - Oral diseases

JF - Oral diseases

ER -

Non-smoking and Non-drinking Oral Cancer Patients Are at Higher Risk of Second Primary Tumours

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