Nonalcoholic Fatty Liver Disease: Rapid Evaluation of Liver Fat Content with In-Phase and Out-of-Phase MR Imaging

Ronald J. H. Borra*, Sakari Salo, Kirsti Dean, Riikka Lautamaki, Pirjo Nuutila, Markku Komu, Riitta Parkkola

*Corresponding author voor dit werk

    OnderzoeksoutputAcademicpeer review

    94 Citaten (Scopus)

    Samenvatting

    Purpose: To evaluate in-phase and out-of-phase magnetic resonance (MR) imaging in the estimation of liver fat content (LFC) in patients with nonalcoholic fatty liver disease (NAFLD), with hydrogen (H-1) MR spectroscopy as the reference standard.

    Materials and Methods: Written informed consent was obtained from all subjects, and the local ethics committee approved this prospective study protocol. A total of 33 patients with type 2 diabetes mellitus who were at high risk for NAFLD (23 men, 10 women; overall mean age, 62.8 years +/- .3 [standard deviation]; age range, 48-77 years) underwent 1.5-T MR imaging with H-1 MR spectroscopy and in-phase and out-of-phase imaging of the liver. Three fat indexes were calculated from the signal intensity (SI) measured on the images. Two radiologists independently graded SI changes between in-phase and out-of-phase images by means of visual inspection. The Pearson correlation coefficient was used to study the relationship between the obtained parameters of SI change and LFC measured with H-1 MR spectroscopy.

    Results: Fat indexes calculated from in-phase and out-of-phase images correlated linearly with LFC measured with H-1 MR spectroscopy (P

    Conclusion: In-phase and out-of-phase imaging can be used to rapidly estimate the LFC in patients with NAFLD. The cutoff value of 5.1% enables objective rapid and reliable discrimination of normal LFC from elevated LFC. (C) RSNA, 2008

    Originele taal-2English
    Pagina's (van-tot)130-136
    Aantal pagina's7
    TijdschriftRadiology
    Volume250
    Nummer van het tijdschrift1
    DOI's
    StatusPublished - jan.-2009

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