1 Citaat (Scopus)


As a result of longer survival times, even among patients with incurable malignancies, the prevalence of patients at risk of developing second primary tumours and/or locoregional recurrences in previously irradiated areas might increase. Consequently, the need for additional therapeutic measures providing local control and/or symptom palliation along different lines of treatment has emerged. This has resulted in increasing requests for delivering a second and sometimes even third course of radiation to target volumes within or close to previously irradiated anatomical areas. On the one hand, improved imaging and delivery techniques including image-guided and intensity-modulated radiotherapy might facilitate reirradiation of previously exposed regions of the body. On the other hand, late toxicity is of concern because it often causes serious impact on health-related quality of life. Therefore, knowledge about long-term recovery of occult radiation injury is of utmost importance. This chapter summarises available experimental and clinical data on the effects of reirradiation to various organs.
Originele taal-2English
SubtitelNew Frontiers
RedacteurenCarsten Nieder, Johannes Langendijk
Aantal pagina's368
ISBN van elektronische versie978-3-319-41825-4
ISBN van geprinte versie978-3-319-41823-0
StatusPublished - 2017

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