Novel artificial metalloenzymes by in vivo incorporation of metal-binding unnatural amino acids

Ivana Drienovska, Ana Rioz-Martinez, Apparao Draksharapu, Gerard Roelfes*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

87 Citaten (Scopus)
307 Downloads (Pure)

Samenvatting

Artificial metalloenzymes have emerged as an attractive new approach to enantioselective catalysis. Herein, we introduce a novel strategy for preparation of artificial metalloenzymes utilizing amber stop codon suppression methodology for the in vivo incorporation of metal-binding unnatural amino acids. The resulting artificial metalloenzymes were applied in catalytic asymmetric Friedel-Crafts alkylation reactions and up to 83% ee for the product was achieved.

Originele taal-2English
Pagina's (van-tot)770-776
Aantal pagina's7
TijdschriftChemical Science
Volume6
Nummer van het tijdschrift1
DOI's
StatusPublished - 2015

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