Novel organization of the arginine catabolic mobile element and staphylococcal cassette chromosome mec composite island and its horizontal transfer between distinct Staphylococcus aureus genotypes

Artur J Sabat, Robin Köck, Viktoria Akkerboom, Ron Hendrix, Robert L Skov, Karsten Becker, Alexander W Friedrich

OnderzoeksoutputAcademicpeer review

14 Citaten (Scopus)


In this study, 425 methicillin-resistant Staphylococcus aureus (MRSA) isolates recovered in the Dutch-German Euregio were investigated for the presence of the arginine catabolic mobile element (ACME). Sequence analysis by whole-genome sequencing revealed an entirely new organization of the ACME-staphylococcal cassette chromosome mec composite island (SCCmec-CI), with truncated ACME type II located downstream of SCCmec. An identical nucleotide sequence of ACME-SCCmec-CI was found in two distinct MRSA lineages (t064-ST8 and t002-ST5), which has not been reported previously in S. aureus.

Originele taal-2English
Pagina's (van-tot)5774-5777
Aantal pagina's4
TijdschriftAntimicrobial Agents and Chemotherapy
Nummer van het tijdschrift11
StatusPublished - nov-2013

Citeer dit