Numerical simulation of the influence of a left ventricular assist device on the cardiovascular system

GJ Verkerke*, AA Geertsema, D Mihaylov, PK Blanksma, G Rakhorst

*Bijbehorende auteur voor dit werk

Onderzoeksoutput: ArticleAcademicpeer review

7 Citaten (Scopus)


The PUCA (pulsatile catheter) pump is a left ventricular assist device (LVAD) capable of unloading the left ventricle (LV) and improving coronary flow by providing a counterpulsation effect. If consists of an extracorporeal located membrane pump, coupled to a transarterial catheter that enters the body via a superficial artery and ends in the LV. Blood is aspirated from the LV and pumped in the ascending aorta through the same catheter guided by a valve system. Timing and frequency of the PUCA pump influence its efficacy. To study the influence of several pump parameters a numerical model of the device and the circulatory system has been developed. Results of animal experiments were used to validate the model.

Optimization studies resulted in a pump configuration with a stroke volume of 50 cc and pump:heart frequency mode of 1:2 that starts ejection at the beginning of diastole.

Originele taal-2English
Pagina's (van-tot)765-773
Aantal pagina's9
TijdschriftInternational journal of artificial organs
Nummer van het tijdschrift11
StatusPublished - nov.-2000

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