Nutritional status in children with cancer: Prevalence, related factors, and consequences of malnutrition

Aeltsje Brinksma

Nutritional status in children with cancer: Prevalence, related factors, and consequences of malnutrition

Vertaalde titel van de bijdrage: Voedingstoestand bij kinderen met kanker: Prevalentie, verklarende factoren en gevolgen van een slechte voedingstoestand

Aeltsje Brinksma

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Een slechte voedingstoestand heeft bij kinderen met kanker ernstige gevolgen voor hun overlevingskansen en kwaliteit van leven. De Pecannut studie onderzocht de voedingstoestand bij kinderen met kanker en is met ruim 130 respondenten één van de grootste studies op dit gebied. Uit het onderzoek blijkt dat bij diagnose meer kinderen een slechte voedingstoestand hebben dan tot nu toe gedacht omdat vaak niet bekend is dat kinderen afgevallen zijn. Na het starten van de behandeling heeft 35% van de kinderen ernstig gewichtsverlies en heeft 17% een te lage spiermassa. In de loop van de behandeling nemen echter gewicht en vetmassa toe en verdubbelt het aantal kinderen met overgewicht. De belangrijkste oorzaken voor deze toename zijn het toedienen van sondevoeding en te weinig bewegen. Uit het onderzoek blijkt verder dat kinderen met kanker niet meer maar juist minder energie nodig hebben omdat ze weinig actief zijn.
Kinderen met gewichtsverlies hebben een hogere kans op infecties en ondervoede kinderen hebben slechtere overlevingskansen. Bovendien ervaren zowel ondervoede kinderen als kinderen met overgewicht een slechtere kwaliteit van leven dan de kinderen in een goede voedingstoestand.
Dit onderzoek laat zien dat bij kinderen met kanker de problematiek rondom de voedingstoestand divers is, dat de gevolgen van een slechte voedingstoestand ernstig zijn en dat adequaat voeden, tijdig stoppen met sondevoeding en meer bewegen uiterst belangrijk zijn. Daarom is de afdeling Kinderoncologie vervolgonderzoek gestart waarin hulpverleners samen met kinderen en ouders programma’s ontwikkelen gericht op adequaat eten en bewegen. De resultaten zullen in vervolgonderzoek geëvalueerd worden.

Vertaalde titel van de bijdrage	Voedingstoestand bij kinderen met kanker: Prevalentie, verklarende factoren en gevolgen van een slechte voedingstoestand
Originele taal-2	English
Kwalificatie	Doctor of Philosophy
Toekennende instantie	Rijksuniversiteit Groningen
Begeleider(s)/adviseur	Roodbol, Petrie, Supervisor Sanderman, Robbert, Supervisor de Bont, Eveline, Supervisor Tissing, Wim, Co-supervisor
Datum van toekenning	1-okt.-2014
Plaats van publicatie	[S.l.]
Uitgever	[S.n.]
Gedrukte ISBN's	978-90-367-7186-3
Elektronische ISBN's	978-90-367-7185-6
Status	Published - 2014

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Title and contentsFinal publisher's version, 95,2 KB
Chapter 1Final publisher's version, 2,08 MB
Chapter 2Final publisher's version, 2,03 MB
Chapter 3Final publisher's version, 1,96 MB
Chapter 4Final publisher's version, 1,91 MB
Chapter 5Final publisher's version, 1,82 MB
Chapter 6Final publisher's version, 1,88 MB
Chapter 7Final publisher's version, 1,83 MB
Chapter 8Final publisher's version, 1,9 MB
Chapter 9Final publisher's version, 1,74 MB
AppendicesFinal publisher's version, 315 KB
Complete dissertationFinal publisher's version, 5,6 MB
PropositionsFinal publisher's version, 527 KB

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@phdthesis{4a6d90bd39a54774a5f454e8f6c619d6,

title = "Nutritional status in children with cancer: Prevalence, related factors, and consequences of malnutrition",

abstract = "An inadequate nutritional status during treatment for childhood cancer has substantial implications for both survival rates and quality of life. With more than 130 participants, the Pecannut study is one of the largest studies to examine nutritional status in children with cancer. The study demonstrated that at diagnosis more children were malnourished than the literature indicates because weight loss is generally not included in the assessment of nutritional status. After the start of treatment, 35% of the children had significant weight loss, and 17% had muscle wasting. During the first year after diagnosis, however, weight and fat mass increased and the percentage of overnourished children doubled. The main contributory factors to this increase were tube feeding and low levels of physical activity. Energy requirements were decreased because the children were inactive.Weight loss was associated with a higher risk of infections, and undernourished children had lower survival rates. In addition, both undernourished and overnourished children experienced worse health-related quality of life than well-nourished children with cancer.In sum:• the issues regarding nutritional status in children with cancer are complex;• malnutrition is associated with serious consequences;• providing adequate nutritional support, stopping tube feeding in due time, and increasing physical activity are central to improving nutritional status. Based on these outcomes, the Department of Pediatric Oncology has started a project in which health professionals collaborate with children and parents to develop tools that improve dietary intake and stimulate physical activity. Results of the project will be evaluated in follow-up research.",

author = "Aeltsje Brinksma",

year = "2014",

language = "English",

isbn = "978-90-367-7186-3",

publisher = "[S.n.]",

school = "University of Groningen",

}

TY - BOOK

T1 - Nutritional status in children with cancer

T2 - Prevalence, related factors, and consequences of malnutrition

AU - Brinksma, Aeltsje

PY - 2014

Y1 - 2014

N2 - An inadequate nutritional status during treatment for childhood cancer has substantial implications for both survival rates and quality of life. With more than 130 participants, the Pecannut study is one of the largest studies to examine nutritional status in children with cancer. The study demonstrated that at diagnosis more children were malnourished than the literature indicates because weight loss is generally not included in the assessment of nutritional status. After the start of treatment, 35% of the children had significant weight loss, and 17% had muscle wasting. During the first year after diagnosis, however, weight and fat mass increased and the percentage of overnourished children doubled. The main contributory factors to this increase were tube feeding and low levels of physical activity. Energy requirements were decreased because the children were inactive.Weight loss was associated with a higher risk of infections, and undernourished children had lower survival rates. In addition, both undernourished and overnourished children experienced worse health-related quality of life than well-nourished children with cancer.In sum:• the issues regarding nutritional status in children with cancer are complex;• malnutrition is associated with serious consequences;• providing adequate nutritional support, stopping tube feeding in due time, and increasing physical activity are central to improving nutritional status. Based on these outcomes, the Department of Pediatric Oncology has started a project in which health professionals collaborate with children and parents to develop tools that improve dietary intake and stimulate physical activity. Results of the project will be evaluated in follow-up research.

AB - An inadequate nutritional status during treatment for childhood cancer has substantial implications for both survival rates and quality of life. With more than 130 participants, the Pecannut study is one of the largest studies to examine nutritional status in children with cancer. The study demonstrated that at diagnosis more children were malnourished than the literature indicates because weight loss is generally not included in the assessment of nutritional status. After the start of treatment, 35% of the children had significant weight loss, and 17% had muscle wasting. During the first year after diagnosis, however, weight and fat mass increased and the percentage of overnourished children doubled. The main contributory factors to this increase were tube feeding and low levels of physical activity. Energy requirements were decreased because the children were inactive.Weight loss was associated with a higher risk of infections, and undernourished children had lower survival rates. In addition, both undernourished and overnourished children experienced worse health-related quality of life than well-nourished children with cancer.In sum:• the issues regarding nutritional status in children with cancer are complex;• malnutrition is associated with serious consequences;• providing adequate nutritional support, stopping tube feeding in due time, and increasing physical activity are central to improving nutritional status. Based on these outcomes, the Department of Pediatric Oncology has started a project in which health professionals collaborate with children and parents to develop tools that improve dietary intake and stimulate physical activity. Results of the project will be evaluated in follow-up research.

M3 - Thesis fully internal (DIV)

SN - 978-90-367-7186-3

PB - [S.n.]

CY - [S.l.]

ER -

Nutritional status in children with cancer: Prevalence, related factors, and consequences of malnutrition

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