Obesity-related polymorphisms and their associations with the ability to regulate fat oxidation in obese Europeans: The NUGENOB study

Eva Corpeleijn, Liselotte Petersen, Claus Holst, Wim H Saris, Arne Astrup, Dominique Langin, Ian MacDonald, J Alfredo Martinez, Jean-Michel Oppert, Jan Polak, Oluf Pedersen, Philippe Froguel, Peter Arner, Thorkild I A Sørensen, Ellen E Blaak

OnderzoeksoutputAcademicpeer review

38 Citaten (Scopus)


Both obesity and insulin resistance have been related to low fat oxidation rates, which may be genetically determined. The association between variation in fat oxidation rates among obese subjects and genotype was studied for 42 common single-nucleotide polymorphisms (SNPs) in 26 candidate genes for fat oxidation, insulin resistance, and obesity, including FTO. Energy expenditure (EE) and fat oxidation were measured with indirect calorimetry during fasting and 3 h after a high fat load containing 95 energy% of fat (60% saturated fat, energy content 50% of estimated resting EE) in 722 obese subjects (541 women, 181 men) from 8 European centers. After adjustment for center and gender, -178 A>C CD36 (rs2232169) (P = 0.02), -22510 C>G SLC6A14 (women, rs2011162) (P = 0.03), and T690S C>G PCSK1 (rs6235) (P = 0.02) were related to a reduced fat oxidation, whereas 17 C>G SREBF1 (17 C>G) (P = 0.01) was related to increased fat oxidation in the fasting state. The ability to increase fat oxidation after a high fat load was increased in subjects with -174 G>C IL6 (rs1800795) (P = 0.01). Effect sizes range from 1.1 to 3.1% differences in fat oxidation (expressed as % of EE). FTO rs9939609 was not related to fat oxidation. At the same time, the results are not adjusted for multiple testing, thus none of the associations can be considered statistically significant. The results should therefore only be considered as leads to new hypotheses about effects of specific genetic polymorphisms on fasting and postprandial fat oxidation.

Originele taal-2English
Pagina's (van-tot)1369-1377
Aantal pagina's9
TijdschriftObesity (Silver Spring, Md.)
Nummer van het tijdschrift7
StatusPublished - jul-2010
Extern gepubliceerdJa

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