One pot 'click' reactions: tandem enantioselective biocatalytic epoxide ring opening and [3+2] azide alkyne cycloaddition

Lachlan S. Campbell-Verduyn, Wiktor Szymanski, Christiaan P. Postema, Rudi A. Dierckx, Philip H. Elsinga*, Dick B. Janssen, Ben L. Feringa

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

95 Citaten (Scopus)
2 Downloads (Pure)


Halohydrin dehalogenase (HheC) can perform enantioselective azidolysis of aromatic epoxides to 1,2-azido alcohols which are subsequently ligated to alkynes producing chiral hydroxy triazoles in a one-pot procedure with excellent enantiomeric excess.

Originele taal-2English
Pagina's (van-tot)898-900
Aantal pagina's3
TijdschriftChemical Communications
Nummer van het tijdschrift6
StatusPublished - 2010

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