One-pot, modular approach to functionalized ketones via nucleophilic addition/Buchwald-Hartwig amination strategy

Jorn de Jong, Dorus Heijnen, Hugo Helbert, Ben L. Feringa*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

5 Citaten (Scopus)
77 Downloads (Pure)


A general one-pot procedure for the 1,2-addition of organolithium reagents to amides followed by the Buchwald-Hartwig amination with in situ released lithium amides is presented. In this work amides are used as masked ketones, revealed by the addition of organolithium reagents which generates a lithium amide, suitable for subsequent Buchwald-Hartwig coupling in the presence of a palladium catalyst. This methodology allows for rapid, efficient and atom economic synthesis of aminoarylketones in good yields.

Originele taal-2English
Pagina's (van-tot)2908-2911
Aantal pagina's4
TijdschriftChemical Communications
Nummer van het tijdschrift20
StatusPublished - 11-mrt-2019

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