Samenvatting
A general one-pot procedure for the 1,2-addition of organolithium reagents to amides followed by the Buchwald-Hartwig amination with in situ released lithium amides is presented. In this work amides are used as masked ketones, revealed by the addition of organolithium reagents which generates a lithium amide, suitable for subsequent Buchwald-Hartwig coupling in the presence of a palladium catalyst. This methodology allows for rapid, efficient and atom economic synthesis of aminoarylketones in good yields.
Originele taal-2 | English |
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Pagina's (van-tot) | 2908-2911 |
Aantal pagina's | 4 |
Tijdschrift | Chemical Communications |
Volume | 55 |
Nummer van het tijdschrift | 20 |
DOI's | |
Status | Published - 11-mrt.-2019 |