One-pot synthesis of 6-l-[18f] fluoro-3,4-dihydroxyphenylalanine (6-l-[18f] fdopa).

Geert Luurtsema (Uitvinder), Chantal Kwizera (Uitvinder), Simon Niels Blok (Uitvinder), Ines Farinha Antunes (Uitvinder), Philippus Hein Elsinga (Uitvinder), Erik de Vries (Uitvinder)

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Samenvatting

The invention relates to the field of medicinal chemistry and radiopharmaceuticals, in particular to means, methods and cassettes for the automated synthesis of the radiotracer 6-L-[18F]fluoro-3,4- dihydroxyphenylalanine (6-L-[18F]FDOPA). Provided is a method for the one-pot synthesis of 6-L-[18F]FDOPA comprising contacting a BOC- protected stannyl precursor of the formula I with [18F] Tetraethylammonium fluoride ([18F]Et4NF) in the presence of the Cu-catalyst Cu(Impy)4(OTf)2.
Originele taal-2English
OctrooinummerWO2024058665
Prioriteitsdatum15/09/2022
Indieningsdatum14/09/2023
StatusPublished - 21-mrt.-2024

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