One-year severity of depressive symptoms: Results from the NESDA study

F. Lamers, A.T. Beekman, P. de Jonge, J.H. Smit, W.A. Nolen, B.W. Penninx

OnderzoeksoutputAcademicpeer review

10 Citaten (Scopus)
323 Downloads (Pure)


The aim of this study was to simultaneously examine a wide range of risk factors and clinical characteristics in their predictive value for the one-year severity of depressive symptoms. Data from 789 participants in the Netherlands Study of Depression and Anxiety (NESDA), a large psychiatric cohort study, with a major depressive disorder (MDD) at baseline were used. Depression severity at one-year follow-up was studied using linear and multinomial logistic regression models. Results of the analyses showed that high neuroticism, no partner and older age were found predictive of a poorer outcome independent of baseline clinical characteristics. Further, comorbid anxiety disorder, first episode, having a moderate subtype (vs. melancholic), and higher baseline depression severity predicted poorer outcome. To conclude, both risk factors and clinical characteristics independently predicted one-year severity of depressive symptoms. This implies that the prediction of prognosis and identification of persons at risk of a poor outcome should not only be based on clinical characteristics, but on risk factors as well
Originele taal-2English
Pagina's (van-tot)226-231
Aantal pagina's6
TijdschriftPsychiatry Research
Nummer van het tijdschrift2-3
StatusPublished - 30-dec-2011

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