TY - JOUR
T1 - Operating characteristics of depression and anxiety disorder phenotype dimensions and trait neuroticism
T2 - A theoretical examination of the fear and distress disorders from the Netherlands study of depression and anxiety
AU - Tully, Phillip J.
AU - Wardenaar, Klaas J.
AU - Penninx, Brenda W. J. H.
N1 - Copyright © 2014 Elsevier B.V. All rights reserved.
PY - 2015/3/15
Y1 - 2015/3/15
N2 - Background: The receiver operating characteristics (ROC) of anhedonic depression and anxious arousal to detect the distress- (major depression, dysthymia, generalized anxiety disorder) and fear-disorder clusters (i.e. panic disorder, agoraphobia, social phobia) have not been reported in a large sample.Methods: A sample of 2981 persons underwent structured psychiatric interview; n=652 were without lifetime depression and anxiety disorder history. Participants also completed a neuroticism scale (Revised NEO Five Factor Inventory [NEO-FFI]), and the 30-item short adaptation of the Mood and Anxiety Symptoms Questionnaire (MASQ-D30) measuring anhedonic depression, anxious arousal and general distress. Maximal sensitivity and specificity was determined by the Youden Index and the area-under-the-curve (AUC) in ROC analysis.Results: A total of 2624 completed all measures (age M=42.4 years +/- 13.1, 1760 females [67.1%]), including 1060 (40.4%) persons who met criteria for a distress-disorder, and 973 (37.1%) who met criteria for a fear-disorder. The general distress dimension provided the highest ROC values in the detection of the distress-disorders (AUC=.814, sensitivity-71.95%, specificity-76.34%, positive predictive value-67.33, negative predictive value=80.07). None of the measures provided suitable operating characteristics in the detection of the fear-disorders with specificity valuesConclusions: The MASQ-D30 general distress dimension showed clinically suitable operating characteristics in the detection of distress-disorders. Neither neuroticism nor the MASQ-D30 dimensions provided suitable operating characteristics in the detection of the fear-disorders. (C) 2014 Elsevier B.V. All rights reserved.
AB - Background: The receiver operating characteristics (ROC) of anhedonic depression and anxious arousal to detect the distress- (major depression, dysthymia, generalized anxiety disorder) and fear-disorder clusters (i.e. panic disorder, agoraphobia, social phobia) have not been reported in a large sample.Methods: A sample of 2981 persons underwent structured psychiatric interview; n=652 were without lifetime depression and anxiety disorder history. Participants also completed a neuroticism scale (Revised NEO Five Factor Inventory [NEO-FFI]), and the 30-item short adaptation of the Mood and Anxiety Symptoms Questionnaire (MASQ-D30) measuring anhedonic depression, anxious arousal and general distress. Maximal sensitivity and specificity was determined by the Youden Index and the area-under-the-curve (AUC) in ROC analysis.Results: A total of 2624 completed all measures (age M=42.4 years +/- 13.1, 1760 females [67.1%]), including 1060 (40.4%) persons who met criteria for a distress-disorder, and 973 (37.1%) who met criteria for a fear-disorder. The general distress dimension provided the highest ROC values in the detection of the distress-disorders (AUC=.814, sensitivity-71.95%, specificity-76.34%, positive predictive value-67.33, negative predictive value=80.07). None of the measures provided suitable operating characteristics in the detection of the fear-disorders with specificity valuesConclusions: The MASQ-D30 general distress dimension showed clinically suitable operating characteristics in the detection of distress-disorders. Neither neuroticism nor the MASQ-D30 dimensions provided suitable operating characteristics in the detection of the fear-disorders. (C) 2014 Elsevier B.V. All rights reserved.
KW - Depression disorders
KW - Anxiety disorders
KW - Mood and Anxiety Symptoms Questionnaire
KW - Receiver-operating characteristic analysis
KW - Screening
KW - COMMON MENTAL-DISORDERS
KW - SYMPTOM QUESTIONNAIRE MASQ
KW - TRIPARTITE MODEL
KW - PRIMARY-CARE
KW - DISCRIMINANT VALIDITY
KW - CLINICAL-SAMPLE
KW - MOOD DISORDERS
KW - YOUNG-ADULTS
KW - COMORBIDITY
KW - PERSONALITY
U2 - 10.1016/j.jad.2014.12.045
DO - 10.1016/j.jad.2014.12.045
M3 - Article
C2 - 25577156
SN - 0165-0327
VL - 174
SP - 611
EP - 618
JO - Journal of Affective Disorders
JF - Journal of Affective Disorders
ER -