Samenvatting
Selection of a single bacterial strain out of a mixture of microorganisms is of crucial importance in healthcare and microbiology research. Novel approaches that can externally control bacterial selection are a valuable addition to the microbiology toolbox. In this proof-of-concept, two complementary antibiotics are protected with photocleavable groups that can be orthogonally addressed with different wavelengths of light. This allows for the light-triggered selection of a single bacterial strain out of a mixture of multiple strains, by choosing the right wavelength. Further improvement toward additional orthogonally addressable antibiotics might ultimately lead to a novel methodology for bacterial selection in complex populations.
Originele taal-2 | English |
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Pagina's (van-tot) | 1969-1974 |
Aantal pagina's | 6 |
Tijdschrift | ACS chemical biology |
Volume | 9 |
Nummer van het tijdschrift | 9 |
DOI's | |
Status | Published - sep.-2014 |