Orthogonal photoswitching in a multifunctional molecular system

Michael M. Lerch, Mickel J. Hansen, Willem A. Velema, Wiktor Szymanski, Ben L. Feringa

OnderzoeksoutputAcademicpeer review

127 Citaten (Scopus)
374 Downloads (Pure)

Samenvatting

The wavelength-selective, reversible photocontrol over various molecular processes in parallel remains an unsolved challenge. Overlapping ultraviolet-visible spectra of frequently employed photoswitches have prevented the development of orthogonally responsive systems, analogous to those that rely on wavelength-selective cleavage of photo-removable protecting groups. Here we report the orthogonal and reversible control of two distinct types of photoswitches in one solution, that is, a donor-acceptor Stenhouse adduct (DASA) and an azobenzene. The control is achieved by using three different wavelengths of irradiation and a thermal relaxation process. The reported combination tolerates a broad variety of differently substituted photoswitches. The presented system is also extended to an intramolecular combination of photoresponsive units. A model application for an intramolecular combination of switches is presented, in which the DASA component acts as a phase-transfer tag, while the azobenzene moiety independently controls the binding to alpha-cyclodextrin.

Originele taal-2English
Artikelnummer12054
Aantal pagina's10
TijdschriftNature Communications
Volume7
DOI's
StatusPublished - jul-2016

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