Oxidative stress and macrophages: driving forces behind exacerbations of asthma and chronic obstructive pulmonary disease?

Linsey Elisabeth Susan de Groot, T Anienke van der Veen, Fernando O Martinez, Jörg Hamann, Rene Lutter, Barbro N Melgert

Onderzoeksoutput: Review articleAcademicpeer review

20 Citaten (Scopus)
142 Downloads (Pure)


Oxidative stress is a common feature of obstructive airway diseases like asthma and chronic obstructive pulmonary disease (COPD). Lung macrophages are key innate immune cells that can generate oxidants and are known to display aberrant polarization patterns and defective phagocytic responses in these diseases. Whether these characteristics are linked in one way or another and whether they contribute to the onset and severity of exacerbations in asthma and COPD remains poorly understood. Insight into oxidative stress, macrophages and their interactions may be important in fully understanding acute worsening of lung disease. This review therefore highlights the current state of the art regarding the role of oxidative stress and macrophages in exacerbations of asthma and COPD. It shows that oxidative stress can attenuate macrophage function, which may result in impaired responses towards exacerbating triggers and may contribute to exaggerated inflammation in the airways.

Originele taal-2English
Pagina's (van-tot)L369-L384
Aantal pagina's16
TijdschriftAmerican Journal of Physiology - Lung Cellular and Molecular Physiology
Nummer van het tijdschrift2
Vroegere onlinedatum6-dec-2018
StatusPublished - feb-2019

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