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The discovery of an ultrafast cross-coupling of alkyland aryllithium reagents with a range of aryl bromides is presented. The essential role of molecular oxygen to form the active palladium catalyst was established; palladium nanoparticles that are highly active in cross-coupling reactions with reaction times ranging from 5 s to 5 min are thus generated in situ. High selectivities were observed for a range of heterocycles and functional groups as well as for an expanded scope of organolithium reagents. The applicability of this method was showcased by the synthesis of the [C-11]-labeled PET tracer celecoxib.

Originele taal-2English
Pagina's (van-tot)3354-3359
Aantal pagina's6
TijdschriftAngewandte Chemie - International Edition
Nummer van het tijdschrift12
Vroegere onlinedatum14-feb-2017
StatusPublished - 13-mrt-2017

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