P-NGAL Day 1 predicts early but not one year graft function following deceased donor kidney transplantation - The CONTEXT study

Marie B. Nielsen*, Nicoline V. Krogstrup, Gertrude J. Nieuwenhuijs-Moeke, Mihai Oltean, Frank J. M. F. Dor, Bente Jespersen, Henrik Birn

*Bijbehorende auteur voor dit werk

    OnderzoeksoutputAcademicpeer review

    5 Citaten (Scopus)
    129 Downloads (Pure)

    Samenvatting

    Background

    Early markers to predict delayed kidney graft function (DGF) may support clinical management. We studied the ability of four biomarkers (neutrophil gelatinase associated lipocalin (NGAL), liver-type fatty acid-binding protein (L-FABP), cystatin C, and YKL-40) to predict DGF after deceased donor transplantation, and their association with early graft function and GFR at three and twelve months.

    Methods

    225 deceased donor kidney transplant recipients were included. Biomarkers were measured using automated assays or ELISA. We calculated their ability to predict the need for dialysis post-transplant and correlated with the estimated time to a 50% reduction in plasma creatinine (tCr50), measured glomerular filtration rate (mGFR) and estimated GFR (eGFR).

    Results

    All biomarkers measured at Day 1, except urinary L-FABP, significantly correlated with tCr50 and mGFR at Day 5. Plasma NGAL at Day 1 and a timed urine output predicted DGF (AUC = 0.91 and AUC 0.98). Nil or only weak correlations were identified between early bio-arker levels and mGFR or eGFR at three or twelve months.

    Conclusion

    High plasma NGAL at Day 1 predicts DGF and is associated with initial graft function, but may not prove better than P-creatinine or a timed urine output. Early biomarker levels do not correlate with one-year graft function.

    Trial registration

    ClinicalTrials.gov NCT01395719

    Originele taal-2English
    Artikelnummer0212676
    Aantal pagina's14
    TijdschriftPLoS ONE
    Volume14
    Nummer van het tijdschrift2
    DOI's
    StatusPublished - 28-feb-2019

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