Parkinson's disease: leucine-rich repeat kinase 2 and autophagy, intimate enemies

José M Bravo-San Pedro, Rubén Gómez-Sánchez, Elisa Pizarro-Estrella, Mireia Niso-Santano, Rosa A González-Polo, José M Fuentes Rodríguez

Onderzoeksoutputpeer review

6 Citaten (Scopus)
37 Downloads (Pure)

Samenvatting

Parkinson's disease is the second common neurodegenerative disorder, after Alzheimer's disease. It is a clinical syndrome characterized by loss of dopamine-generating cells in the substancia nigra, a region of the midbrain. The etiology of Parkinson's disease has long been through to involve both genetic and environmental factors. Mutations in the leucine-rich repeat kinase 2 gene cause late-onset Parkinson's disease with a clinical appearance indistinguishable from Parkinson's disease idiopathic. Autophagy is an intracellular catabolic mechanism whereby a cell recycles or degrades damage proteins and cytoplasmic organelles. This degradative process has been associated with cellular dysfunction in neurodegenerative processes including Parkinson's disease. We discuss the role of leucine-rich repeat kinase 2 in autophagy, and how the deregulations of this degradative mechanism in cells can be implicated in the Parkinson's disease etiology.

Originele taal-2English
Artikelnummer151039
Aantal pagina's9
TijdschriftParkinsons disease
Volume2012
DOI's
StatusPublished - 2012
Extern gepubliceerdJa

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