Partial-volume effect and a partial-volume correction for the NanoPET/CT™ preclinical PET/CT scanner

Istvan Szanda*, Lefteris Livieratos, Gergely Patay, Charalampos Tsoumpas, Kavitha Sunassee, Gregory E. Mullen, Gabor Nemeth, Peter Major, Paul K. Marsden

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)

Samenvatting

The partial-volume effect (PVE) can compromise the quantitative accuracy of preclinical positron emission tomogprahy (PET) images. We investigated this effect by simulating a NEMA NU4 mouse Image Quality Phantom (including calculation of a spatially variant position-dependent point spread function (PSF) ) as well as measuring it. Three different types of deconvolution-based partial- volume corrections were applied: the Lucy-Richardson (LR), Van Cittert (VC) and Wiener (WNR) algorithms. For simulation and phantom measurement, partial-volume correction was applied. Based on optimal parameters the same methods were used to correct data of a mouse study acquired with the NanoPET/CT™ preclinical scanner (Mediso Ltd. Budapest, Hungary and and Bioscan Inc., Washington DC, USA). The algorithms used successfully improve the values of recovery coefficients to varying extents both in simulation and measurement. The preliminary mouse study shows improvement in quantification. Full validation is subject to further investigation.

Originele taal-2English
Titel2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
UitgeverijInstitute of Electrical and Electronics Engineers Inc.
Pagina's3605-3609
Aantal pagina's5
ISBN van geprinte versie9781467301183
DOI's
StatusPublished - 2011
Extern gepubliceerdJa
Evenement2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011 - Valencia, Spain
Duur: 23-okt.-201129-okt.-2011

Publicatie series

NaamIEEE Nuclear Science Symposium Conference Record
ISSN van geprinte versie1095-7863

Conference

Conference2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
Land/RegioSpain
StadValencia
Periode23/10/201129/10/2011

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