TY - GEN
T1 - Partial-volume effect and a partial-volume correction for the NanoPET/CT™ preclinical PET/CT scanner
AU - Szanda, Istvan
AU - Livieratos, Lefteris
AU - Patay, Gergely
AU - Tsoumpas, Charalampos
AU - Sunassee, Kavitha
AU - Mullen, Gregory E.
AU - Nemeth, Gabor
AU - Major, Peter
AU - Marsden, Paul K.
PY - 2011
Y1 - 2011
N2 - The partial-volume effect (PVE) can compromise the quantitative accuracy of preclinical positron emission tomogprahy (PET) images. We investigated this effect by simulating a NEMA NU4 mouse Image Quality Phantom (including calculation of a spatially variant position-dependent point spread function (PSF) ) as well as measuring it. Three different types of deconvolution-based partial- volume corrections were applied: the Lucy-Richardson (LR), Van Cittert (VC) and Wiener (WNR) algorithms. For simulation and phantom measurement, partial-volume correction was applied. Based on optimal parameters the same methods were used to correct data of a mouse study acquired with the NanoPET/CT™ preclinical scanner (Mediso Ltd. Budapest, Hungary and and Bioscan Inc., Washington DC, USA). The algorithms used successfully improve the values of recovery coefficients to varying extents both in simulation and measurement. The preliminary mouse study shows improvement in quantification. Full validation is subject to further investigation.
AB - The partial-volume effect (PVE) can compromise the quantitative accuracy of preclinical positron emission tomogprahy (PET) images. We investigated this effect by simulating a NEMA NU4 mouse Image Quality Phantom (including calculation of a spatially variant position-dependent point spread function (PSF) ) as well as measuring it. Three different types of deconvolution-based partial- volume corrections were applied: the Lucy-Richardson (LR), Van Cittert (VC) and Wiener (WNR) algorithms. For simulation and phantom measurement, partial-volume correction was applied. Based on optimal parameters the same methods were used to correct data of a mouse study acquired with the NanoPET/CT™ preclinical scanner (Mediso Ltd. Budapest, Hungary and and Bioscan Inc., Washington DC, USA). The algorithms used successfully improve the values of recovery coefficients to varying extents both in simulation and measurement. The preliminary mouse study shows improvement in quantification. Full validation is subject to further investigation.
U2 - 10.1109/NSSMIC.2011.6153678
DO - 10.1109/NSSMIC.2011.6153678
M3 - Conference contribution
AN - SCOPUS:84858676878
SN - 9781467301183
T3 - IEEE Nuclear Science Symposium Conference Record
SP - 3605
EP - 3609
BT - 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
PB - Institute of Electrical and Electronics Engineers Inc.
T2 - 2011 IEEE Nuclear Science Symposium and Medical Imaging Conference, NSS/MIC 2011
Y2 - 23 October 2011 through 29 October 2011
ER -