Pd-Catalyzed de Novo Assembly of Diversely Substituted Indole-Fused Polyheterocycles

Qian Wang, Angelina Osipyan, Markella Konstantinidou, Roberto Butera, Kumchok C. Mgimpatsang, Svitlana V. Shishkina, Alexander Dömling*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

11 Citaten (Scopus)
229 Downloads (Pure)


Here we describe a facile, tandem synthetic route for indolo[3,2-c]quinolinones, a class of natural alkaloid analogues of high biological significance. A Ugi four-component reaction with indole-2-carboxylic acid and an aniline followed by a Pd-catalyzed cyclization yields tetracyclic indoloquinolines in good to moderate yields. Commercially available building blocks yield highly diverse analogues in just two simple steps.
Originele taal-2English
Pagina's (van-tot)12148-12156
Aantal pagina's9
TijdschriftThe Journal of Organic Chemistry
Nummer van het tijdschrift18
StatusPublished - 20-sep.-2019

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