Performance Testing of a Homemade Aerosol Generator for Pulmonary Administration of Dry Powder Formulations to Mice

Rick Heida, Paul Hagedoorn, Melle C. Van Meel, Remco Prins, Frederike Simonis, Renate Akkerman, H.W. Frijlink, Anke Huckriede, Anne de Boer, Wouter Hinrichs*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

2 Citaten (Scopus)
36 Downloads (Pure)

Samenvatting

A challenge in the development of dry powder formulations for inhalation is the poor reproducibility of their administration to small laboratory animals. The currently used devices for the pulmonary administration of dry powder formulations to small rodents often function sub-optimally as they use the same puff of air for both powder dispersion and aerosol delivery. As a result, either the air volume and flow rate are too low for complete powder deagglomeration or they are too high for effective aerosol delivery to the lungs of the animal. Therefore, novel and better devices are desired. We here present an aerosol generator designed to administer a pre-generated aerosol to the lungs of mice. By mapping the complex relationship between the airflow rate, delivery time and emitted dose, we were able to control the amount of powder being delivered from the aerosol generator. The emitted aerosol had a size range favorable for lung deposition and could be measured reproducibly. Nevertheless, in vivo fluorescent imaging still revealed considerable differences between the mice in terms of the dose deposited and the distribution of powder over the lungs, suggesting that a certain biological variation in lung deposition is inevitable.

Originele taal-2English
Artikelnummer1847
Aantal pagina's15
TijdschriftPharmaceutics
Volume15
Nummer van het tijdschrift7
DOI's
StatusPublished - 28-jun.-2023

Vingerafdruk

Duik in de onderzoeksthema's van 'Performance Testing of a Homemade Aerosol Generator for Pulmonary Administration of Dry Powder Formulations to Mice'. Samen vormen ze een unieke vingerafdruk.

Citeer dit