Perioperative Systemic Therapy vs Cytoreductive Surgery and Hyperthermic Intraperitoneal Chemotherapy Alone for Resectable Colorectal Peritoneal Metastases A Phase 2 Randomized Clinical Trial

Dutch Peritoneal Oncology Grp, Dutch Colorectal Canc Grp, Koen P. Rovers, Checca Bakkers, Simon W. Nienhuijs, Jacobus W. A. Burger, Geert-Jan M. Creemers, Anna M. J. Thijs, Alexandra R. M. Brandt-Kerkhof, Eva V. E. Madsen, Esther van Meerten, Jurriaan B. Tuynman, Miranda Kusters, Kathelijn S. Versteeg, Arend G. J. Aalbers, Niels F. M. Kok, Tineke E. Buffart, Marinus J. Wiezer, Djamila Boerma, Maartje LosPhilip R. de Reuver, Andreas J. A. Bremers, Henk M. W. Verheul, Schelto Kruijff, Derk Jan A. de Groot, Arjen J. Witkamp, Wilhelmina M. U. van Grevenstein, Miriam Koopman, Joost Nederend, Max J. Lahaye, Onno Kranenburg, Remond J. A. Fijneman, Iris van 't Erve, Petur Snaebjornsson, Patrick H. J. Hemmer, Marcel G. W. Dijkgraaf, Cornelis J. A. Punt, Pieter J. Tanis, Ignace H. J. T. de Hingh*

*Bijbehorende auteur voor dit werk

OnderzoeksoutputAcademicpeer review

9 Citaten (Scopus)
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IMPORTANCE To date, no randomized clinical trials have investigated perioperative systemic therapy relative to cytoreductive surgery and hyperthermic intraperitoneal chemotherapy (CRS-HIPEC) alone for resectable colorectal peritoneal metastases (CPM).

OBJECTIVE To assess the feasibility and safety of perioperative systemic therapy in patients with resectable CPM and the response of CPM to neoadjuvant treatment.

DESIGN, SETTING, AND PARTICIPANTS An open-label, parallel-group phase 2 randomized clinical trial in all 9 Dutch tertiary centers for the surgical treatment of CPM enrolled participants between June 15, 2017, and January 9, 2019. Participants were patients with pathologically proven isolated resectable CPM who did not receive systemic therapy within 6 months before enrollment.

INTERVENTIONS Randomization to perioperative systemic therapy or CRS-HIPEC alone. Perioperative systemic therapy comprised either four 3-week neoadjuvant and adjuvant cycles of CAPOX (capecitabine and oxaliplatin), six 2-week neoadjuvant and adjuvant cycles of FOLFOX (fluorouracil, leucovorin, and oxaliplatin), or six 2-week neoadjuvant cycles of FOLFIRI (fluorouracil, leucovorin, and irinotecan) and either four 3-week adjuvant cycles of capecitabine or six 2-week adjuvant cycles of fluorouracil with leucovorin. Bevacizumab was added to the first 3 (CAPOX) or 4 (FOLFOX/FOLFIRI) neoadjuvant cycles.

MAIN OUTCOMES AND MEASURES Proportions of macroscopic complete CRS-HIPEC and Clavien-Dindo grade 3 or higher postoperative morbidity. Key secondary outcomes were centrally assessed rates of objective radiologic and major pathologic response of CPM to neoadjuvant treatment. Analyses were done modified intention-to-treat in patients starting neoadjuvant treatment (experimental arm) or undergoing upfront surgery (control arm).

RESULTS In 79 patients included in the analysis (43 [54%] men; mean [SD] age, 62 [10] years), experimental (n = 37) and control (n = 42) arms did not differ significantly regarding the proportions of macroscopic complete CRS-HIPEC (33 of 37 [89%] vs 36 of 42 [86%] patients; risk ratio, 1.04; 95% CI, 0.88-1.23; P=.74) and Clavien-Dindo grade 3 or higher postoperative morbidity (8 of 37 [22%] vs 14 of 42 [33%] patients; risk ratio, 0.65; 95% CI, 0.31-1.37; P=.25). No treatment-related deaths occurred. Objective radiologic and major pathologic response rates of CPM to neoadjuvant treatment were 28%(9 of 32 evaluable patients) and 38%(13 of 34 evaluable patients), respectively.

CONCLUSIONS AND RELEVANCE In this randomized phase 2 trial in patients diagnosed with resectable CPM, perioperative systemic therapy seemed feasible, safe, and able to induce response of CPM, justifying a phase 3 trial.

Originele taal-2English
Pagina's (van-tot)710-720
Aantal pagina's11
TijdschriftJAMA Surgery
Nummer van het tijdschrift8
Vroegere onlinedatum19-mei-2021
StatusPublished - aug-2021

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