Personality Polygenes, Positive Affect, and Life Satisfaction

Alexander Weiss; Bart M. L. Baselmans; Edith Hofer; Jingyun Yang; Aysu Okbay; Penelope A. Lind; Mike B. Miller; Ilja M. Nolte; Wei Zhao; Saskia P. Hagenaars; Jouke-Jan Hottenga; Lindsay K. Matteson; Harold Snieder; Jessica D. Faul; Catharina A. Hartman; Patricia A. Boyle; Henning Tiemeier; Miriam A. Mosing; Alison Pattie; Gail Davies; David C. Liewald; Reinhold Schmidt; Philip L. De Jager; Andrew C. Heath; Markus Jokela; John M. Starr; Albertine J. Oldehinkel; Magnus Johannesson; David Cesarini; Albert Hofman; Sarah E. Harris; Jennifer A. Smith; Liisa Keltikangas-Jaervinen; Laura Pulkki-Raback; Helena Schmidt; Jacqui Smith; William G. Iacono; Matt McGue; David A. Bennett; Nancy L. Pedersen; Patrik K. E. Magnusson; Ian J. Deary; Nicholas G. Martin; Dorret I. Boomsma; Meike Bartels; Michelle Luciano

doi:10.1017/thg.2016.65

Personality Polygenes, Positive Affect, and Life Satisfaction

Alexander Weiss, Bart M. L. Baselmans, Edith Hofer, Jingyun Yang, Aysu Okbay, Penelope A. Lind, Mike B. Miller, Ilja M. Nolte, Wei Zhao, Saskia P. Hagenaars, Jouke-Jan Hottenga, Lindsay K. Matteson, Harold Snieder, Jessica D. Faul, Catharina A. Hartman, Patricia A. Boyle, Henning Tiemeier, Miriam A. Mosing, Alison Pattie, Gail DaviesDavid C. Liewald, Reinhold Schmidt, Philip L. De Jager, Andrew C. Heath, Markus Jokela, John M. Starr, Albertine J. Oldehinkel, Magnus Johannesson, David Cesarini, Albert Hofman, Sarah E. Harris, Jennifer A. Smith, Liisa Keltikangas-Jaervinen, Laura Pulkki-Raback, Helena Schmidt, Jacqui Smith, William G. Iacono, Matt McGue, David A. Bennett, Nancy L. Pedersen, Patrik K. E. Magnusson, Ian J. Deary, Nicholas G. Martin, Dorret I. Boomsma, Meike Bartels, Michelle Luciano^*

^*Corresponding author voor dit werk

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Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes

Originele taal-2	English
Pagina's (van-tot)	407-417
Aantal pagina's	11
Tijdschrift	Twin research and human genetics
Volume	19
Nummer van het tijdschrift	5
DOI's	https://doi.org/10.1017/thg.2016.65
Status	Published - okt.-2016

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10.1017/thg.2016.65Licentie: CC BY

Personality Polygenes, Positive Affect, and Life SatisfactionFinal publisher's version, 307 KBLicentie: CC BY

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Weiss, A., Baselmans, B. M. L., Hofer, E., Yang, J., Okbay, A., Lind, P. A., Miller, M. B., Nolte, I. M., Zhao, W., Hagenaars, S. P., Hottenga, J.-J., Matteson, L. K., Snieder, H., Faul, J. D., Hartman, C. A., Boyle, P. A., Tiemeier, H., Mosing, M. A., Pattie, A., ... Luciano, M. (2016). Personality Polygenes, Positive Affect, and Life Satisfaction. Twin research and human genetics, 19(5), 407-417. https://doi.org/10.1017/thg.2016.65

@article{049b0418df3849bd9fbf95c3c061d5ac,

title = "Personality Polygenes, Positive Affect, and Life Satisfaction",

abstract = "Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes",

keywords = "wellbeing, genetics, polygenic prediction, happiness, genetic correlation, GENOME-WIDE ASSOCIATION, TRAITS, METAANALYSIS, NEUROTICISM, GENETICS, TWIN, HERITABILITY, HAPPINESS, VARIANTS, DISORDER",

author = "Alexander Weiss and Baselmans, \{Bart M. L.\} and Edith Hofer and Jingyun Yang and Aysu Okbay and Lind, \{Penelope A.\} and Miller, \{Mike B.\} and Nolte, \{Ilja M.\} and Wei Zhao and Hagenaars, \{Saskia P.\} and Jouke-Jan Hottenga and Matteson, \{Lindsay K.\} and Harold Snieder and Faul, \{Jessica D.\} and Hartman, \{Catharina A.\} and Boyle, \{Patricia A.\} and Henning Tiemeier and Mosing, \{Miriam A.\} and Alison Pattie and Gail Davies and Liewald, \{David C.\} and Reinhold Schmidt and \{De Jager\}, \{Philip L.\} and Heath, \{Andrew C.\} and Markus Jokela and Starr, \{John M.\} and Oldehinkel, \{Albertine J.\} and Magnus Johannesson and David Cesarini and Albert Hofman and Harris, \{Sarah E.\} and Smith, \{Jennifer A.\} and Liisa Keltikangas-Jaervinen and Laura Pulkki-Raback and Helena Schmidt and Jacqui Smith and Iacono, \{William G.\} and Matt McGue and Bennett, \{David A.\} and Pedersen, \{Nancy L.\} and Magnusson, \{Patrik K. E.\} and Deary, \{Ian J.\} and Martin, \{Nicholas G.\} and Boomsma, \{Dorret I.\} and Meike Bartels and Michelle Luciano",

year = "2016",

month = oct,

doi = "10.1017/thg.2016.65",

language = "English",

volume = "19",

pages = "407--417",

journal = "Twin research and human genetics",

issn = "1832-4274",

publisher = "Cambridge University Press",

number = "5",

}

Weiss, A, Baselmans, BML, Hofer, E, Yang, J, Okbay, A, Lind, PA, Miller, MB, Nolte, IM, Zhao, W, Hagenaars, SP, Hottenga, J-J, Matteson, LK, Snieder, H, Faul, JD, Hartman, CA, Boyle, PA, Tiemeier, H, Mosing, MA, Pattie, A, Davies, G, Liewald, DC, Schmidt, R, De Jager, PL, Heath, AC, Jokela, M, Starr, JM, Oldehinkel, AJ, Johannesson, M, Cesarini, D, Hofman, A, Harris, SE, Smith, JA, Keltikangas-Jaervinen, L, Pulkki-Raback, L, Schmidt, H, Smith, J, Iacono, WG, McGue, M, Bennett, DA, Pedersen, NL, Magnusson, PKE, Deary, IJ, Martin, NG, Boomsma, DI, Bartels, M & Luciano, M 2016, 'Personality Polygenes, Positive Affect, and Life Satisfaction', Twin research and human genetics, vol. 19, nr. 5, blz. 407-417. https://doi.org/10.1017/thg.2016.65

TY - JOUR

T1 - Personality Polygenes, Positive Affect, and Life Satisfaction

AU - Weiss, Alexander

AU - Baselmans, Bart M. L.

AU - Hofer, Edith

AU - Yang, Jingyun

AU - Okbay, Aysu

AU - Lind, Penelope A.

AU - Miller, Mike B.

AU - Nolte, Ilja M.

AU - Zhao, Wei

AU - Hagenaars, Saskia P.

AU - Hottenga, Jouke-Jan

AU - Matteson, Lindsay K.

AU - Snieder, Harold

AU - Faul, Jessica D.

AU - Hartman, Catharina A.

AU - Boyle, Patricia A.

AU - Tiemeier, Henning

AU - Mosing, Miriam A.

AU - Pattie, Alison

AU - Davies, Gail

AU - Liewald, David C.

AU - Schmidt, Reinhold

AU - De Jager, Philip L.

AU - Heath, Andrew C.

AU - Jokela, Markus

AU - Starr, John M.

AU - Oldehinkel, Albertine J.

AU - Johannesson, Magnus

AU - Cesarini, David

AU - Hofman, Albert

AU - Harris, Sarah E.

AU - Smith, Jennifer A.

AU - Keltikangas-Jaervinen, Liisa

AU - Pulkki-Raback, Laura

AU - Schmidt, Helena

AU - Smith, Jacqui

AU - Iacono, William G.

AU - McGue, Matt

AU - Bennett, David A.

AU - Pedersen, Nancy L.

AU - Magnusson, Patrik K. E.

AU - Deary, Ian J.

AU - Martin, Nicholas G.

AU - Boomsma, Dorret I.

AU - Bartels, Meike

AU - Luciano, Michelle

PY - 2016/10

Y1 - 2016/10

N2 - Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes

AB - Approximately half of the variation in wellbeing measures overlaps with variation in personality traits. Studies of non-human primate pedigrees and human twins suggest that this is due to common genetic influences. We tested whether personality polygenic scores for the NEO Five-Factor Inventory (NEO-FFI) domains and for item response theory (IRT) derived extraversion and neuroticism scores predict variance in wellbeing measures. Polygenic scores were based on published genome-wide association (GWA) results in over 17,000 individuals for the NEO-FFI and in over 63,000 for the IRT extraversion and neuroticism traits. The NEO-FFI polygenic scores were used to predict life satisfaction in 7 cohorts, positive affect in 12 cohorts, and general wellbeing in 1 cohort (maximal N = 46,508). Meta-analysis of these results showed no significant association between NEO-FFI personality polygenic scores and the wellbeing measures. IRT extraversion and neuroticism polygenic scores were used to predict life satisfaction and positive affect in almost 37,000 individuals from UK Biobank. Significant positive associations (effect sizes

KW - wellbeing

KW - genetics

KW - polygenic prediction

KW - happiness

KW - genetic correlation

KW - GENOME-WIDE ASSOCIATION

KW - TRAITS

KW - METAANALYSIS

KW - NEUROTICISM

KW - GENETICS

KW - TWIN

KW - HERITABILITY

KW - HAPPINESS

KW - VARIANTS

KW - DISORDER

U2 - 10.1017/thg.2016.65

DO - 10.1017/thg.2016.65

M3 - Article

C2 - 27546527

SN - 1832-4274

VL - 19

SP - 407

EP - 417

JO - Twin research and human genetics

JF - Twin research and human genetics

IS - 5

ER -

Personality Polygenes, Positive Affect, and Life Satisfaction

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