PET Imaging of Mild Traumatic Brain Injury and Whiplash Associated Disorder

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Traumatic brain injury is the leading cause of brain injury in our society with 235 per 100,000 inhabitants per year in the European Union and about 500 per 100,000 inhabitants per year in the United States. About 80% of all these events are accounted for as mild cases. At the same time, whiplash-associated disorder is one of the most frequent consequences of motor vehicle related accidents affecting about 300 per 100,000 inhabitants per year in the United States and Western European countries.
Both brain injuries are frequently underestimated due to their apparent low severity and because in many cases these symptoms disappear within few weeks. Nevertheless, several patients describe long-lasting discomfort in the absence of detectable alterations with conventional clinical diagnostic tools or imaging studies, such as magnetic resonance imaging (MRI) and computed tomography (CT). Therefore, the mechanism behind the long-lasting manifestations remains unknown. It is within this context that functional imaging techniques, such as positron emission tomography (PET) have the potential to provide insight into the undetected changes related to mild traumatic brain injury and whiplash-associated disorder.
Originele taal-2English
KwalificatieDoctor of Philosophy
Toekennende instantie
  • Rijksuniversiteit Groningen
Begeleider(s)/adviseur
  • Dierckx, Rudi, Supervisor
  • Otte, Andreas, Supervisor, Externe Persoon
  • Doorduin, Janine, Co-supervisor
  • Kremer, Berry, Beoordelingscommissie
  • Lammertsma, Adriaan A., Beoordelingscommissie, Externe Persoon
  • Carrio, I., Beoordelingscommissie, Externe Persoon
Datum van toekenning2-dec-2015
Plaats van publicatie[Groningen]
Uitgever
Gedrukte ISBN's978-90-367-8314-9
Elektronische ISBN's978-90-367-8313-2
StatusPublished - 2015

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